Document Detail

How many days per week should rats undergo running exercise to increase BMD?
MedLine Citation:
PMID:  15981024     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine the effect of different frequencies of running exercise on increasing bone mineral density (BMD) and improving bone histomorphology at various sites of the skeleton (tibia, femur, and second lumbar vertebra) in young rats. Twenty-five female Wistar rats, 8 weeks old, were divided into five groups, of 5 animals each according to running load: control group, no running (A group); running load (RL), 4 days per week (d/w; B group); RL, 5 d/w (C group); RL, 6 d/w (D group); and RL, 7 d/w (E group). Rats ran on a treadmill at a speed of 15 m/min for 30 min per day over an 8-week period. The results indicated that the BMD of the tibia in the B, C, D, and E groups and that of the femur in the B and E groups increased significantly over that of the A group. However, the cortical BMD and trabecular BMD of the second lumbar vertebra did not change. In regard to bone histomorphometry of the tibia, a parameter of bone resorption (eroded surface/bone surface) was significantly lower in the B and D groups than in the A group. There were no differences in the parameters of bone formation. Tartaric acid-resistant acid phosphatase (TRACP) values were significantly lower in the B and C groups than in the A group. There were significant increases in body weight in the B group and in muscle weight in the C group. From the data obtained in this study, it was concluded that increases in BMD were obtained by a moderate running load at frequencies of 4 and 5 days per week.
Yoshinobu Hagihara; Satoshi Fukuda; Sumio Goto; Haruzo Iida; Masashi Yamazaki; Hideshige Moriya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bone and mineral metabolism     Volume:  23     ISSN:  0914-8779     ISO Abbreviation:  J. Bone Miner. Metab.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-10-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9436705     Medline TA:  J Bone Miner Metab     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Department of Orthopedic Surgery, Jyoto Insurance Hospital, 9-13-1 Kameido, Koutou-ku, Tokyo 136-0071, Japan.
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MeSH Terms
Acid Phosphatase / metabolism
Bone Density / physiology*
Bone Resorption / prevention & control
Isoenzymes / metabolism
Osteogenesis / physiology
Physical Conditioning, Animal
Physical Exertion / physiology*
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Isoenzymes; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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