Document Detail

How I manage patients with atypical microcytic anaemia.
MedLine Citation:
PMID:  23057559     Owner:  NLM     Status:  Publisher    
Microcytic hypochromic anaemias are a result of defective iron handling by erythroblasts that decrease the haemoglobin content per red cell. Recent advances in our knowledge of iron metabolism and its homeostasis have led to the discovery of novel inherited anaemias that need to be distinguished from common iron deficiency or other causes of microcytosis. These atypical microcytic anaemias can be classified as: (i) defects of intestinal iron absorption (ii) disorders of the transferrin receptor cycle that impair erythroblast iron uptake (iii) defects of mitochondrial iron utilization for haem or iron sulphur cluster synthesis and (iv) defects of iron recycling. A careful patient history and evaluation of laboratory tests may enable these rare conditions to be distinguished from the more common iron deficiency anaemia. Molecular studies allow distinction of the different types, a prerequisite for differentiated therapy.
Clara Camaschella
Related Documents :
7582699 - Aetiology and presenting symptoms in male osteoporosis.
18069419 - Bone turnover and hip bone mineral density in patients with sarcoidosis.
20557749 - Focal cement accumulation in lytic metastatic lesions: a new sign in vertebroplasty?
20971509 - Erythroid response and decrease of wt1 expression after proteasome inhibition by bortez...
18593769 - Bone quality determined by fourier transform infrared imaging analysis in mild primary ...
23632359 - Decompensated cirrhotics have slower intestinal transit times as compared with compensa...
17488419 - Closure of adult patent ductus arteriosus under cardiopulmonary bypass by using foley b...
8450989 - New-onset seizures in an elderly hospitalized population.
3453969 - Autonomic activity in the carpal tunnel syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inefficient delivery but fast peptide bond formation of unnatural L-aminoacyl-tRNAs in translation.
Next Document:  The human degree of care. Professional loving care for people with a mild intellectual disability: a...