| How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective. | |
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MedLine Citation:
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PMID: 20955418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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I here describe a line of research that grew out of studies of spinal cord-damaging decompression sickness, focused on the blood-endothelial interface, that was influenced by the local Shwartzman phenomenon, addressed innate immune and inflammatory mechanisms, and ultimately arrived at mucosal tolerance approaches to prevent stroke. Intranasal instillation of E-selectin is under development as a novel means of targeting immunomodulation to activating blood vessels within the vascular tree supplying the brain. The goal of this form of focused immunomodulation is to prevent recurrent strokes in patients that have previously suffered transient ischemic attacks or strokes. |
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Authors:
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John Hallenbeck |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1207 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-09 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. hallenbj@ninds.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / blood supply*, physiopathology* E-Selectin / administration & dosage Humans Inflammation / physiopathology* Rats Shwartzman Phenomenon / physiopathology Stroke / prevention & control Tumor Necrosis Factor-alpha / physiology |
| Grant Support | |
ID/Acronym/Agency:
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ZIA NS002924-15/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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