Document Detail

How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective.
MedLine Citation:
PMID:  20955418     Owner:  NLM     Status:  MEDLINE    
I here describe a line of research that grew out of studies of spinal cord-damaging decompression sickness, focused on the blood-endothelial interface, that was influenced by the local Shwartzman phenomenon, addressed innate immune and inflammatory mechanisms, and ultimately arrived at mucosal tolerance approaches to prevent stroke. Intranasal instillation of E-selectin is under development as a novel means of targeting immunomodulation to activating blood vessels within the vascular tree supplying the brain. The goal of this form of focused immunomodulation is to prevent recurrent strokes in patients that have previously suffered transient ischemic attacks or strokes.
John Hallenbeck
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1207     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-09     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
© 2010 New York Academy of Sciences.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Central Nervous System / blood supply*,  physiopathology*
E-Selectin / administration & dosage
Inflammation / physiopathology*
Shwartzman Phenomenon / physiopathology
Stroke / prevention & control
Tumor Necrosis Factor-alpha / physiology
Grant Support
Reg. No./Substance:
0/E-Selectin; 0/Tumor Necrosis Factor-alpha

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