Document Detail


How the immune system talks to itself: the varied role of synapses.
MedLine Citation:
PMID:  23278741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using an elaborately evolved language of cytokines and chemokines as well as cell-cell interactions, the different components of the immune system communicate with each other and orchestrate a response (or wind one down). Immunological synapses are a key feature of the system in the ways in which they can facilitate and direct these responses. Studies analyzing the structure of an immune synapse as it forms between two cells have provided insight into how the stability and kinetics of this interaction ultimately affect the sensitivity, potency, and magnitude of a given response. Furthermore, we have gained an appreciation of how the immunological synapse provides directionality and contextual cues for downstream signaling and cellular decision-making. In this review, we discuss how using a variety of techniques, developed over the last decade, have allowed us to visualize and quantify key aspects of the dynamic synaptic interface and have furthered our understanding of their function. We describe some of the many characteristics of the immunological synapse that make it a vital part of intercellular communication and some of the questions that remain to be answered.
Authors:
Jianming Xie; Cristina M Tato; Mark M Davis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  251     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-28     Revised Date:  2014-01-01    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-79     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication*
Humans
Immune System*
Immunologic Techniques / methods,  trends
Immunological Synapses / immunology*
Protein Binding / immunology
Receptor Cross-Talk / immunology
Signal Transduction / immunology
Grant Support
ID/Acronym/Agency:
U19 AI057229/AI/NIAID NIH HHS; U19 AI090019/AI/NIAID NIH HHS; //Howard Hughes Medical Institute
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.
Next Document:  Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.