| How the immune system talks to itself: the varied role of synapses. | |
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MedLine Citation:
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PMID: 23278741 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Using an elaborately evolved language of cytokines and chemokines as well as cell-cell interactions, the different components of the immune system communicate with each other and orchestrate a response (or wind one down). Immunological synapses are a key feature of the system in the ways in which they can facilitate and direct these responses. Studies analyzing the structure of an immune synapse as it forms between two cells have provided insight into how the stability and kinetics of this interaction ultimately affect the sensitivity, potency, and magnitude of a given response. Furthermore, we have gained an appreciation of how the immunological synapse provides directionality and contextual cues for downstream signaling and cellular decision-making. In this review, we discuss how using a variety of techniques, developed over the last decade, have allowed us to visualize and quantify key aspects of the dynamic synaptic interface and have furthered our understanding of their function. We describe some of the many characteristics of the immunological synapse that make it a vital part of intercellular communication and some of the questions that remain to be answered. |
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Authors:
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Jianming Xie; Cristina M Tato; Mark M Davis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 251 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 65-79 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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