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How has neutrophil research improved our understanding of periodontal pathogenesis?
MedLine Citation:
PMID:  21323704     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nussbaum G, Shapira L: How has neutrophil research improved our understanding of periodontal pathogenesis? J Clin Periodontol 2011; 38 (Suppl. 11): 49-59. doi: 10.1111/j.1600-051X.2010.01678.x. ABSTRACT: Background: Neutrophils are the predominant cells responsible for host defence against bacterial infection. Loss of neutrophil defence, due either to deficient number or function, strongly predisposes to bacterial infections such as periodontitis. Yet, the neutrophil oxidative and proteolytic arsenal has also been implicated in perpetrating periodontal tissue damage in periodontitis. Aim: In this review, we focus on recent developments that shed light on these two aspects of neutrophil function in periodontitis. Methods: Primary search: using PubMed search for "neutophil", "periodontal", and "periodontitis". Secondary search: using references from the articles found in the first stage. Results: Early histological studies showed that infiltrating neutrophils form a wall of cells abutting the junctional epithelium in periodontal inflammatory lesions. The chronic standoff between these neutrophils and the bacterial community suggests that bacterial evasion of neutrophil clearance is a major characteristic of periodontitis. Indeed, not all functional neutrophil deficiencies increase the risk of periodontitis, an observation that points the way towards identification of particular anti-bacterial pathways essential for protection against periodontal pathogens. The net result in the majority of periodontitis patients who exhibit normal neutrophil number and function, is that neutrophils accumulate in the periodontal tissue where they are available to participate in tissue destruction. Diminished neutrophil clearance further contributes to the persistence of activated neutrophils in the periodontal tissue. Conclusions: Data on the role of neutrophils in the pathogenesis of periodontitis are mixed. Neutrophils are a critical arm of the defence against periodontitis, but bacterial evasion of the neutrophil microbicidal machinery coupled with delayed neutrophil apoptosis may transform the neutrophil from defender to perpetrator. At this stage of knowledge, attempts to induce host modulation through neutrophil suppression or activation are premature.
Authors:
Gabriel Nussbaum; Lior Shapira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  38 Suppl 11     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  49-59     Citation Subset:  D; IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel Department of Periodontology, Faculty of Dental Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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