Document Detail


How has DISC1 enabled drug discovery?
MedLine Citation:
PMID:  18055216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growing genetic and clinical evidence has shown that disrupted-in-schizophrenia 1 (DISC1) is one of the most compelling risk genes for schizophrenia and other major mental disorders. The understanding of the role that DISC1 plays in neuronal development and cell signaling has been greatly enhanced by the identification of DISC1 binding partners, an appreciation of its expression during development and functional studies using RNA interference. But what is the impact of this explosion of data for psychiatric drug discovery? Though we are at a very early stage of our understanding of DISC1 biology, it is an important time to review what has already been achieved and to discuss its impact. DISC1 biology has enabled the identification of new therapeutic targets in the form of DISC1 binding partners and other molecules found within a large DISC1 interaction network, the so-called 'DISC1 interactome'. We will review the better characterized of these interactions and also emphasize the richness of potential targets in the more poorly studied areas of the interactome. Furthermore, DISC1 has encouraged the development of new animal models for psychiatric disorders, which is critical for the study of disease biology. Thus, DISC1 may have the potential to not only point us in the direction of novel drug targets but also provide more relevant animal models for compound testing.
Authors:
Qi Wang; Hanna Jaaro-Peled; Akira Sawa; Nicholas J Brandon
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-10-23
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  37     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Affiliation:
Discovery Neuroscience, Wyeth Research, Princeton, NJ, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology*,  metabolism*,  physiopathology
Carrier Proteins / genetics,  metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4 / genetics,  metabolism
Delirium, Dementia, Amnestic, Cognitive Disorders / drug therapy,  genetics,  metabolism*
Disease Models, Animal
Drug Design
Genetic Predisposition to Disease / genetics*
Humans
Nerve Tissue Proteins / genetics*
Synaptic Transmission / genetics
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/DISC1 protein, human; 0/NDEL1 protein, human; 0/Nerve Tissue Proteins; EC 3.1.4.17/Cyclic Nucleotide Phosphodiesterases, Type 4

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