Document Detail

How dynein helps the cell find its center: a servomechanical model.
MedLine Citation:
PMID:  15953546     Owner:  NLM     Status:  MEDLINE    
Cytoplasmic dynein is the major minus-end-directed microtubule motor protein in interphase cells. In addition to its well-established roles in vesicular transport and chromosome dynamics, cytoplasmic dynein also associates with the cell cortex. From this site, it appears to pull on the cytoplasmic microtubule network, influencing mitotic spindle orientation, nuclear position and other aspects of cell polarity and organization. Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior.
Richard B Vallee; Stephanie A Stehman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  15     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2006-09-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  288-94     Citation Subset:  IM    
Department of Pathology & Anatomy, Columbia University College of Physicians and Surgeons, P&S 15-409, 630 W 168th St, New York, NY 10032, USA.
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MeSH Terms
Cell Cycle
Cell Movement
Cell Polarity*
Centrosome / metabolism
Dyneins / metabolism*
Models, Biological*
Reg. No./Substance:

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