| How dynein helps the cell find its center: a servomechanical model. | |
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MedLine Citation:
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PMID: 15953546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytoplasmic dynein is the major minus-end-directed microtubule motor protein in interphase cells. In addition to its well-established roles in vesicular transport and chromosome dynamics, cytoplasmic dynein also associates with the cell cortex. From this site, it appears to pull on the cytoplasmic microtubule network, influencing mitotic spindle orientation, nuclear position and other aspects of cell polarity and organization. Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior. |
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Authors:
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Richard B Vallee; Stephanie A Stehman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cell biology Volume: 15 ISSN: 0962-8924 ISO Abbreviation: Trends Cell Biol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-14 Completed Date: 2006-09-06 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 288-94 Citation Subset: IM |
Affiliation:
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Department of Pathology & Anatomy, Columbia University College of Physicians and Surgeons, P&S 15-409, 630 W 168th St, New York, NY 10032, USA. rv2025@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Cell Movement Cell Polarity* Centrosome / metabolism Dyneins / metabolism* Models, Biological* |
| Chemical | |
Reg. No./Substance:
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EC 3.6.4.2/Dyneins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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