| How does diabetes accelerate Alzheimer disease pathology? | |
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MedLine Citation:
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PMID: 20842183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes and Alzheimer disease (AD)-two age-related diseases-are both increasing in prevalence, and numerous studies have demonstrated that patients with diabetes have an increased risk of developing AD compared with healthy individuals. The underlying biological mechanisms that link the development of diabetes with AD are not fully understood. Abnormal protein processing, abnormalities in insulin signaling, dysregulated glucose metabolism, oxidative stress, the formation of advanced glycation end products, and the activation of inflammatory pathways are features common to both diseases. Hypercholesterolemia is another factor that has received attention, owing to its potential association with diabetes and AD. This Review summarizes the mechanistic pathways that might link diabetes and AD. An understanding of this complex interaction is necessary for the development of novel drug therapies and lifestyle guidelines aimed at the treatment and/or prevention of these diseases. |
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Authors:
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Catrina Sims-Robinson; Bhumsoo Kim; Andrew Rosko; Eva L Feldman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-14 |
Journal Detail:
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Title: Nature reviews. Neurology Volume: 6 ISSN: 1759-4766 ISO Abbreviation: Nat Rev Neurol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-07 Completed Date: 2011-01-27 Revised Date: 2011-10-24 |
Medline Journal Info:
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Nlm Unique ID: 101500072 Medline TA: Nat Rev Neurol Country: England |
Other Details:
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Languages: eng Pagination: 551-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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complications,
epidemiology,
metabolism,
pathology* Diabetes Mellitus / epidemiology, physiopathology* Disease Progression Glycogen Synthase Kinases / metabolism Humans Insulin / metabolism Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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T32 AG000114-26/AG/NIA NIH HHS; T32-AG000114/AG/NIA NIH HHS; U01-DK076160/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; EC 2.7.11.-/Glycogen Synthase Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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