| How does antifungal pharmacology differ for mucormycosis versus aspergillosis? | |
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MedLine Citation:
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PMID: 22247448 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Over the last decade, advances in diagnostic systems and the introduction of new antifungal agents have significantly improved outcomes in immunocompromised patients who develop invasive aspergillosis. However, mortality rates remain relatively unchanged for less common, but highly aggressive, mold infections such as mucormycosis. Recent genome sequencing of Rhizopus oryzae revealed evidence of a whole-genome duplication event during the evolution of this pathogen. Consequently, R. oryzae has a 2- to 10-fold enrichment in gene families associated with ergosterol and cell wall biosynthesis, cell growth, iron uptake, and known fungal virulence factors compared with sequenced Aspergillus fumigatus strains. This genetic plasticity may explain the remarkable capability of this pathogen for rapid growth in hostile environments, such as the inflammatory milieu, as well as its relative resistance to multiple antifungal classes. Herein, we examine how pharmacological aspects of treating mucormycosis may differ from those of the more commonly encountered invasive aspergillosis. |
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Authors:
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Russell E Lewis; Olivier Lortholary; Brad Spellberg; Emmanuel Roilides; Dimitrios P Kontoyiannis; Thomas J Walsh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 54 Suppl 1 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: S67-72 Citation Subset: IM |
Affiliation:
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Department of College of Pharmacy, The University of Houston, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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