Document Detail

How disturbed sleep may be a risk factor for adverse pregnancy outcomes.
MedLine Citation:
PMID:  19296861     Owner:  NLM     Status:  MEDLINE    
Adverse pregnancy outcomes associated with significant maternal and infant morbidity are on the rise in Western society despite advances of medical technology. Current risk factors are insufficient to identify women at greatest risk of developing an adverse outcome. An attempt to identify novel contributors to increased risk is warranted. Sleep disturbances are frequent during pregnancy, yet are often dismissed as irrelevant. Emerging evidence indicates that sleep disturbances are associated with poor health outcomes, including cardiovascular disease. Disturbed sleep is also linked with an increased inflammatory response. Increased inflammation is proposed as a key biological pathway through which chronic disease and adverse pregnancy outcomes develop. In this paper, we propose a model and a testable hypothesis of how disturbed sleep in the first 20 weeks of pregnancy could contribute to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, and preterm birth via increased inflammation. Target Audience: Obstetricians & Gynecologists, Family Physicians Leaning Objectives: After completion of this article, the reader should be able to outline data linking sleep disturbances with an increased risk of some systemic disorders, recall characteristics of pregnancy complications which support the hypothesis that sleep disturbances may be related to these pregnancy outcomes, and summarize the likelihood and types of sleep disturbances that are common in pregnant women.
Michele L Okun; James M Roberts; Anna L Marsland; Martica Hall
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  64     ISSN:  1533-9866     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-05-05     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA.
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MeSH Terms
Infant, Newborn
Inflammation / etiology*
Pregnancy Complications / etiology*
Pregnancy Outcome
Risk Factors
Sleep Disorders / complications*
Grant Support
K99 NR010813-02/NR/NINR NIH HHS; NR010813/NR/NINR NIH HHS; R00 NR010813-05/NR/NINR NIH HHS

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