Document Detail


How cancer metabolism is tuned for proliferation and vulnerable to disruption.
MedLine Citation:
PMID:  23151579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer metabolism has received a substantial amount of interest over the past decade. The advances in analytical tools have, along with the rapid progress of cancer genomics, generated an increasingly complex understanding of metabolic reprogramming in cancer. As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic.
Authors:
Almut Schulze; Adrian L Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  491     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2012-11-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  364-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Humans
Lipids / biosynthesis
Mitochondria / metabolism
Neoplasms / diagnosis,  metabolism*,  physiopathology,  therapy
Oncogenes / physiology
Signal Transduction
Tumor Suppressor Proteins / metabolism
Grant Support
ID/Acronym/Agency:
11359//Cancer Research UK; //Cancer Research UK
Chemical
Reg. No./Substance:
0/Lipids; 0/Tumor Suppressor Proteins
Comments/Corrections
Erratum In:
Nature. 2013 Feb 7;494(7435):130

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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