| How cancer metabolism is tuned for proliferation and vulnerable to disruption. | |
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MedLine Citation:
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PMID: 23151579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer metabolism has received a substantial amount of interest over the past decade. The advances in analytical tools have, along with the rapid progress of cancer genomics, generated an increasingly complex understanding of metabolic reprogramming in cancer. As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic. |
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Authors:
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Almut Schulze; Adrian L Harris |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature Volume: 491 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: 2012-11-30 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 364-73 Citation Subset: IM |
Affiliation:
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Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. almut.schulze@cancer.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Humans Lipids / biosynthesis Mitochondria / metabolism Neoplasms / diagnosis, metabolism*, physiopathology, therapy Oncogenes / physiology Signal Transduction Tumor Suppressor Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Tumor Suppressor Proteins |
| Comments/Corrections | |
Erratum In:
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Nature. 2013 Feb 7;494(7435):130 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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