Document Detail


[How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies].
MedLine Citation:
PMID:  20655695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inflammatory myopathies are a group of quite proteiform, systemic auto-immune diseases which include polymyositis, dermatomyositis and inclusion body myopathies. To facilitate the diagnosis, classification criteria (Bohan and Peter, 1975) have been proposed, based essentially on clinical criteria. In addition, over the past fifteen years, auto-antibodies characterizing certain forms of inflammatory myopathy have been identified. One distinguishes schematically: auto-antibodies specific for myositis and auto-antibodies sometimes associated with myositis. Concerning the myositis specific auto-antibodies (MSA), schematically there are a dozen specificities which are classed according to the cellular distribution of the auto-antigen. The most characteristic are certainly the auto-antibodies directed against cytoplasmic antigens: the anti-tRNA synthetases (anti-Jo-1 (PL-1), anti-PL-7, PL-12, EJ, OJ, JS, KS, ZO, YRS), anti-SRP (signal recognition particle), anti-Mas and anti-KJ, anti-Fer (eEF1), anti-Wa and anti-CADM p140. Other auto-antibodies are directed against nuclear auto-antigens: the anti-Mi-2, anti-PMS (PMS1, PMS2) and related antibodies (MLH1, DNA PKcs…), anti-56 kDa, anti-MJ (NXP-2), anti-SAE and anti-p155/p140 (TIF-1γ). Concerning the auto-antibodies sometimes associated with myositis (myositis associated auto-antibodies or MAA), they can also be observed in other auto-immune diseases. These auto-antibodies are directed against nuclear or nucleolar auto-antigens: the anti-PM-Scl, anti-Ku, anti-RNP (U1 RNP and U2 RNP, U4/U6 RNP and U5 RNP), anti-Ro 52 kDa and more rarely, anti-Ro 60 kDa and anti-La. The auto-antibodies related to myositis are biological tools which are of interest in two main ways. They have allowed us to sort out the nosology of these inflammatory myopathies, in particular by defining anti-tRNA synthetase syndrome. It now remains to determine how they might be employed to complement the classical clinico-biological diagnostic criteria. In this perspective, it will be indispensable first of all to diffuse and standardize the methods of detection. The latter are at the moment very heterogeneous as they use techniques and above all antigenic preparations which are extremely diverse. These antibodies are also very interesting "physiopathological" tools to try to better understand myositis. The example of anti-tRNA synthetases is a particularly original model of auto-immunization, which allows one to establish a link between an initial, probably poorly specific muscular lesion and the appearance of auto-antibodies which maintain and aggravate the muscular disease.
Authors:
Jean Sibilia; Emmanuel Chatelus; Alain Meyer; Jacques-Eric Gottenberg; Christelle Sordet; Joëlle Goetz
Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-07-23
Journal Detail:
Title:  Presse médicale (Paris, France : 1983)     Volume:  39     ISSN:  0755-4982     ISO Abbreviation:  Presse Med     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2010-11-02     Revised Date:  2012-08-14    
Medline Journal Info:
Nlm Unique ID:  8302490     Medline TA:  Presse Med     Country:  France    
Other Details:
Languages:  fre     Pagination:  1010-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
CHU de Strasbourg, hôpital Hautepierre, service de rhumatologie, laboratoire d'immunologie, 67098 Strasbourg cedex, France. jean.sibilia@wanadoo.fr
Vernacular Title:
Comment faire le diagnostic et mieux comprendre les myopathies inflammatoires? L'utilité des auto-anticorps.
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MeSH Terms
Descriptor/Qualifier:
Amino Acyl-tRNA Synthetases / immunology
Animals
Autoantibodies / diagnostic use*,  immunology
Autoantigens / immunology
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Histidine-tRNA Ligase / immunology
Humans
Immunoblotting
Immunodiffusion
Immunologic Factors / diagnostic use*,  immunology
Mi-2 Nucleosome Remodeling and Deacetylase Complex / immunology
Myositis / classification,  diagnosis*,  epidemiology,  immunology*
Proto-Oncogene Proteins / immunology
Receptors, G-Protein-Coupled / immunology
Ribonucleoprotein, U1 Small Nuclear / immunology
Ribonucleoproteins / immunology
Sensitivity and Specificity
Signal Recognition Particle / immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/CHD4 protein, human; 0/Immunologic Factors; 0/Proto-Oncogene Proteins; 0/Receptors, G-Protein-Coupled; 0/Ribonucleoprotein, U1 Small Nuclear; 0/Ribonucleoproteins; 0/SS-A antigen; 0/Signal Recognition Particle; 0/proto-oncogene proteins c-mas-1; EC 3.1.13.-/EXOSC10 protein, human; EC 3.5.1.98/Mi-2 Nucleosome Remodeling and Deacetylase Complex; EC 6.1.1.-/Amino Acyl-tRNA Synthetases; EC 6.1.1.21/Histidine-tRNA Ligase

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