Document Detail

How can ultrafine particles be responsible for increased mortality?
MedLine Citation:
PMID:  10949875     Owner:  NLM     Status:  MEDLINE    
The link between particulate air pollution at relatively low levels and adverse effects both in the lungs and of the cardiovascular system remains a puzzling event. The authors have developed a hypothesis which suggests that ultrafine components of particulate air pollution may result in local and systemic oxidative stress, which produces lung inflammation, but also the systemic effects, resulting in mortality in susceptible individuals from cerebrovascular disease. Preliminary data in vitro and in vivo suggest that both local and systemic oxidative stress occur in response to ultrafine particles and that the effects of such oxidative stress on pro-inflammatory gene regulation and changes in blood coagulation may result in the adverse effects of particulate air pollution. In this article, the evidence which supports this hypothesis is reviewed.
W MacNee; K Donaldson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  55     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-11     Completed Date:  2000-09-11     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Unit of Respiratory Medicine, Royal Infirmary of Edinburgh, University of Edinburgh, UK.
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MeSH Terms
Air Pollutants / adverse effects*
Lung Diseases / mortality,  physiopathology*
Lung Diseases, Obstructive / mortality,  physiopathology
Oxidative Stress / physiology*
Particle Size
Pulmonary Circulation
Reg. No./Substance:
0/Air Pollutants

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