Document Detail

How can oncogenic transcription factors cause cancer: a critical review of the myb story.
MedLine Citation:
PMID:  10482978     Owner:  NLM     Status:  MEDLINE    
Many transcription factors have been found to be oncogenic either when functionally altered through fusion with other proteins or through deregulated expression. However, still little is understood about the mechanism by which these proteins can transform cells of different origin. The Myb transcription factor is emblematic in this respect. Several forms of Myb can transform hematopoietic cells of different lineages in the chicken and Myb has been shown to be required for murine fetal hematopoiesis and to regulate the growth and differentiation of hematopoietic cells of several animal species. The role of the transcriptional activity of Myb and its possible gene targets in transformation are critically discussed.
M Introna; J Golay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Leukemia     Volume:  13     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1301-6     Citation Subset:  IM    
The Molecular Immunohematology Laboratory, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
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MeSH Terms
Cell Differentiation / physiology
Cell Transformation, Neoplastic / genetics*
Hematopoietic Stem Cells / physiology
Neoplasm Staging
Oncogene Proteins v-myb
Retroviridae Proteins, Oncogenic / genetics
Transcription Factors / genetics*
Reg. No./Substance:
0/Oncogene Proteins v-myb; 0/Retroviridae Proteins, Oncogenic; 0/Transcription Factors

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