Document Detail

How big is too big? The perinatal consequences of fetal macrosomia.
MedLine Citation:
PMID:  18455528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to examine the birthweight at which risks of perinatal death, neonatal morbidity, and cesarean delivery begin to rise and the causes and timing (antenatal, early or late neonatal, or postneonatal) of these risks. STUDY DESIGN: This was a cohort study based on 1999-2001 US-linked stillbirth, live birth, and infant death records. Singletons weighing 2500 g or larger born to white non-Hispanic mothers at 37-44 weeks of gestation were selected (n = 5,983,409). RESULTS: Infants with birthweights from 4000 to 4499 g were not at increased risk of mortality or morbidity vs those at 3500-3999 g, whereas those 4500-4999 g had significantly increased risks of stillbirth, neonatal mortality (especially because of birth asphyxia), birth injury, neonatal asphyxia, meconium aspiration, and cesarean delivery. Births at 5000 g or larger had even higher risks, including risk of sudden infant death syndrome. CONCLUSION: Birthweight greater than 4500 g, and especially greater than 5000 g, is associated with increased risks of perinatal and infant mortality and morbidity.
Xun Zhang; Adriana Decker; Robert W Platt; Michael S Kramer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517.e1-6     Citation Subset:  AIM; IM    
Department of Pediatrics, McGill University Faculty of Medicine, Montreal, QC, Canada.
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MeSH Terms
Asphyxia Neonatorum / epidemiology
Birth Injuries / epidemiology
Cesarean Section / statistics & numerical data
Extraction, Obstetrical / statistics & numerical data
Fetal Macrosomia / epidemiology*
Infant, Newborn
Meconium Aspiration Syndrome / epidemiology
Pregnancy Outcome*
Retrospective Studies
Stillbirth / epidemiology
United States / epidemiology
Comment In:
Am J Obstet Gynecol. 2008 May;198(5):603-4; discussion e1-5   [PMID:  18455546 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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