Document Detail


How benign is hematuria? Using genetics to predict prognosis.
MedLine Citation:
PMID:  23325022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hematuria is a common presenting feature of glomerular disease and is sometimes associated with kidney failure later in life. Where isolated microscopic hematuria occurs in children and young adults, an underlying monogenic disorder, such as Alport syndrome or thin basement membrane nephropathy, is frequently responsible. In this review, these and other diseases, which often present with isolated microscopic hematuria, including hereditary angiopathy, nephropathy, aneurysms, and muscle cramps (HANAC) syndrome, IgA nephropathy, and CFHR5 nephropathy, are discussed together with the associated molecular pathology, clinical features, and prognosis. Genetic testing for these conditions used in clinical practice can provide important diagnostic and prognostic information that is relevant to the patient and their family, particularly when kidney transplantation is considered.
Authors:
Daniel P Gale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-17
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  28     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-04     Completed Date:  2014-02-19     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1183-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Female
Genetic Diseases, Inborn / complications,  diagnosis,  genetics*,  therapy
Genetic Predisposition to Disease
Genetic Testing
Hematuria / diagnosis,  genetics*,  therapy
Humans
Kidney Transplantation / adverse effects
Male
Phenotype
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Tissue Donors
Urogenital Abnormalities / complications,  diagnosis,  genetics*,  therapy
Grant Support
ID/Acronym/Agency:
G1002528//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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