Document Detail

How anti-neutrophil cytoplasmic autoantibodies activate neutrophils.
MedLine Citation:
PMID:  22861361     Owner:  NLM     Status:  MEDLINE    
Neutrophils are pivotal to host defence during infectious diseases. However, activated neutrophils may also cause undesired tissue damage. Ample examples include small-vessel inflammatory diseases (vasculitis) that are associated with anti-neutrophil cytoplasmic autoantibodies (ANCA) residing in the patients' plasma. In addition to being an important diagnostic tool, convincing evidence shows that ANCA are pathogenic. ANCA-neutrophil interactions induce important cellular responses that result in highly inflammatory necrotizing vascular damage. The interaction begins with ANCA binding to their target antigens on primed neutrophils, proceeds by recruiting transmembrane molecules to initiate intracellular signal transduction and culminates in activation of effector functions that ultimately mediate the tissue damage.
R Kettritz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  169     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2012-10-16     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Author. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Nephrologie und Internistische Intensivmedizin Charité Virchow Klinikum and Experimental and Clinical Research Center, a joint co-operation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Berlin, Germany.
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MeSH Terms
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology*
Antibodies, Antineutrophil Cytoplasmic / immunology*
Antigen-Antibody Reactions
Antigens, Surface / immunology
Autoantigens / immunology
Cell Membrane / enzymology,  immunology
Cytokines / secretion
GPI-Linked Proteins / immunology
Immunoglobulin Fc Fragments / immunology
Intracellular Membranes / enzymology,  immunology
Lysosome-Associated Membrane Glycoproteins / immunology
Myeloblastin / immunology
Neutrophil Activation / immunology*
Neutrophils / enzymology,  immunology*
Organelles / enzymology,  immunology
Peroxidase / immunology
Phosphatidylinositol 3-Kinases / immunology
Receptors, IgG / immunology
Signal Transduction / immunology
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Antigens, Surface; 0/Autoantigens; 0/Cytokines; 0/FCGR3B protein, human; 0/GPI-Linked Proteins; 0/Immunoglobulin Fc Fragments; 0/LAMP2 protein, human; 0/Lysosome-Associated Membrane Glycoproteins; 0/Receptors, IgG; EC; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC

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