| How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. | |
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MedLine Citation:
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PMID: 21765638 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Natural killer (NK) cells provide an initial host immune response to infection by many viral pathogens. Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral fitness. One mechanism employed by members of the β-herpesvirus family, which includes the cytomegaloviruses, is to modulate the expression of cell surface ligands recognized by NK cell activation molecules. A novel set of cytomegalovirus (CMV) genes, exemplified by the mouse m145 family, encode molecules that have structural and functional features similar to those of host major histocompatibility-encoded (MHC) class I molecules, some of which are known to contribute to immune evasion. In this review, we explore the function, structure, and evolution of MHC-I-like molecules of the CMVs and speculate on the dynamic development of novel immunoevasive functions based on the MHC-I protein fold. |
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Authors:
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Maria Jamela Revilleza; Rui Wang; Janet Mans; Manqing Hong; Kannan Natarajan; David H Margulies |
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Publication Detail:
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Type: Journal Article Date: 2011-06-30 |
Journal Detail:
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Title: Journal of biomedicine & biotechnology Volume: 2011 ISSN: 1110-7251 ISO Abbreviation: J. Biomed. Biotechnol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135740 Medline TA: J Biomed Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 724607 Citation Subset: IM |
Affiliation:
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Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892-1892, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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