| How T cells get grip on lipid antigens. | |
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MedLine Citation:
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PMID: 18065217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid antigens are presented to T cells as complexes formed with CD1 family members. The hydrophobic nature of lipids influences how they remain in biological fluids, are distributed within cells, and are handled to become immunogenic. Continuously expanding knowledge shows how lipids are internalized by APC, traffic through the endocytic system, are processed to generate immunogenic molecules, and are loaded on CD1 proteins. The molecular bases of how lipids interact with CD1 and TCR are being defined. A breakthrough in the field has been the discovery that exogenous and endogenous lipids stimulate T cells which mount adaptive and innate-like responses. Disclosure of molecular protagonists and mechanisms of both responses has great promise for development of novel lipid-based vaccines and immunotherapies. |
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Authors:
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Gennaro De Libero; Lucia Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-12-11 |
Journal Detail:
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Title: Current opinion in immunology Volume: 20 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 96-104 Citation Subset: IM |
Affiliation:
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Experimental Immunology, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland. gennaro.delibero@unibas.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigen Presentation* Antigens / chemistry, immunology, metabolism Antigens, CD1 / metabolism Endoplasmic Reticulum / metabolism Humans Infection / immunology Lipids / chemistry, immunology* Receptors, Antigen, T-Cell / metabolism T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, CD1; 0/Lipids; 0/Receptors, Antigen, T-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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