| How a Hedgehog might see holoprosencephaly. | |
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MedLine Citation:
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PMID: 12668593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Detailed knowledge of the Hedgehog signaling pathway is fundamental to an understanding of vertebrate development as well as several birth defects in humans. Here we review various aspects of Hedgehog synthesis, secretion, distribution and function in the context of the most common anomaly of the developing forebrain in humans, holoprosencephaly. Genetic studies in numerous model organisms are beginning to elucidate the factors that are likely candidates for the causes of early embryonic defects in humans, including holoprosencephaly. |
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Authors:
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Erich Roessler; Maximilian Muenke |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Human molecular genetics Volume: 12 Spec No 1 ISSN: 0964-6906 ISO Abbreviation: Hum. Mol. Genet. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-01 Completed Date: 2003-11-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9208958 Medline TA: Hum Mol Genet Country: England |
Other Details:
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Languages: eng Pagination: R15-25 Citation Subset: IM |
Affiliation:
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Medical Genetics Branch, National Human Genome Research Institute, Bldg 10, 10C103, National Institutes of Health, Bethesda, MD 20892-1852, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / metabolism Disease Models, Animal Gene Expression Regulation Hedgehog Proteins Holoprosencephaly / genetics*, metabolism Humans Models, Biological Models, Genetic Protein Structure, Tertiary Signal Transduction Trans-Activators / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins; 0/Trans-Activators; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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