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How Do We Define Congenital Heart Defects for Scientific Studies?
MedLine Citation:
PMID:  22010848     Owner:  NLM     Status:  Publisher    
Estimates of the prevalence of congenital heart defects (CHD) have been published over many years and from many regions. As they are based on different definitions of which cases to include in the CHD prevalence, published prevalence estimates vary substantially. With the increasing use of echocardiography in neonatal intensive care, a patent ductus arteriosus (PDA) or flow over the atrial septum will often be visible. These findings may be coded as CHD at discharge and in this way falsely increase the CHD prevalence in the population. There are several purposes for which population-based data on CHD may be used: etiology, planning of treatment, or obtain information on outcome, including mortality. For etiology studies, it is important to include terminations of pregnancy as well as all births with CHD. For mortality studies in live births, inclusion of preterm born infants with PDA will increase overall mortality of CHD. The Danish Register of Congenital Heart Disease is based on hospital discharge diagnoses and diagnoses from outpatient visits. To increase the validity of these data, extensive data cleaning has been carried out based on record review and knowledge on the discharge coding practice. We include PDA and atrial septal defects as CHD cases if these defects are still open 2 months after birth. International consensus on how to define CHD would improve the validity and comparability of epidemiological studies on CHD.
Ester Garne; Morten Smaerup Olsen; Søren Paaske Johnsen; Vibeke Hjortdal; Henrik Ørbaek Andersen; Henrik Nissen; Lars Søndergaard; Jørgen Videbaek;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Congenital heart disease     Volume:  -     ISSN:  1747-0803     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Copyright the Authors. Congenital Heart Disease © 2011 Wiley Periodicals, Inc.
Paediatric Department, Hospital Lillebaelt, Kolding, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Department of Cardiothoracic Surgery, Aarhus University Hospital, Skejby, Aarhus, Denmark Department of Cardiothoracic Surgery, Rigshospitalet-Copenhagen University Hospital, Heart Center, Copenhagen, Denmark Department of Cardiology, Odense University Hospital, Odense Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Heart Center, Copenhagen, Denmark.
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