Document Detail


How Are n-3 LCPUFAs Antiarrhythmic? A Reassessment of n-3 LCPUFAs in Cardiac Disease.
MedLine Citation:
PMID:  22953156     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Long-chain n-3-polyunsaturated fatty acids (n-3 LCPUFAs), referring particularly to marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to be effective in treating arrhythmias in some clinical trials and animal studies. The mechanism for this effect of n-3 LCPUFAs is not well understood. Experimental studies and clinical trials published in the 1980s and 1990s suggested that n-3 LCPUFAs may be antiarrhythmic drugs, but more recent trials have not confirmed this. In this paper, we examine evidence for, and against, the direct antiarrhythmic action of n-3 LCPUFAs and suggest that antistructural remodeling effects of n-3 LCPUFAs may be more relevant in accounting for their clinical effects.
Authors:
Andrew Ramadeen; Paul Dorian
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Publication Detail:
Type:  Journal Article     Date:  2012-08-16
Journal Detail:
Title:  Cardiology research and practice     Volume:  2012     ISSN:  2090-0597     ISO Abbreviation:  Cardiol Res Pract     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-06     Completed Date:  2012-09-06     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101516542     Medline TA:  Cardiol Res Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  746709     Citation Subset:  -    
Affiliation:
Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8.
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