| How Are n-3 LCPUFAs Antiarrhythmic? A Reassessment of n-3 LCPUFAs in Cardiac Disease. | |
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MedLine Citation:
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PMID: 22953156 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Long-chain n-3-polyunsaturated fatty acids (n-3 LCPUFAs), referring particularly to marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to be effective in treating arrhythmias in some clinical trials and animal studies. The mechanism for this effect of n-3 LCPUFAs is not well understood. Experimental studies and clinical trials published in the 1980s and 1990s suggested that n-3 LCPUFAs may be antiarrhythmic drugs, but more recent trials have not confirmed this. In this paper, we examine evidence for, and against, the direct antiarrhythmic action of n-3 LCPUFAs and suggest that antistructural remodeling effects of n-3 LCPUFAs may be more relevant in accounting for their clinical effects. |
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Authors:
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Andrew Ramadeen; Paul Dorian |
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Publication Detail:
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Type: Journal Article Date: 2012-08-16 |
Journal Detail:
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Title: Cardiology research and practice Volume: 2012 ISSN: 2090-0597 ISO Abbreviation: Cardiol Res Pract Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-06 Completed Date: 2012-09-06 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 101516542 Medline TA: Cardiol Res Pract Country: United States |
Other Details:
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Languages: eng Pagination: 746709 Citation Subset: - |
Affiliation:
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Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8. |
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