Document Detail

How airway venous malformations differ from airway infantile hemangiomas.
MedLine Citation:
PMID:  21242531     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare airway infantile hemangiomas (IHs) and venous malformations (VMs) clinically, radiographically, endoscopically, and histologically.
DESIGN: Retrospective cohort study.
SETTING: Tertiary care pediatric hospital.
PATIENTS: The study included patients seen in the Vascular Anomaly Clinic, Seattle Children's Hospital, Seattle, Washington, between 2001 and 2008.
METHODS: All patients with airway vascular anomalies were identified by searching the Vascular Anomaly Quality Improvement Database and hospital discharge data. The data, which were analyzed with descriptive statistics and the Fisher exact test, included presenting age, sex, presenting signs, lesion site, and radiographic, endoscopic, and histologic findings..
RESULTS: Seventeen patients with airway lesions were identified, 6 with VMs and 11 with IHs. Patients with VMs presented at a mean (SD) age of 11.3 (13.7) months (age range, 3-39 months), while those with IHs presented at 3 (1.8) months of age (age range, 1-6 months) (P = .03). The patients with IHs were predominantly female (9 of 11 [81%]), while no sex difference was noted among the patients with VMs (3 of 6 [50%]). All patients with IHs presented with stridor and cutaneous lesions, whereas patients with VMs more often presented with hemoptysis or dysphagia (P = .001). Computed tomographic angiograms demonstrated enhancing endolaryngeal lesions in all IHs, while VMs enhanced poorly. Endoscopically, IHs were transglottic, while VMs were postcricoid or epiglottic (P < .001). Histologically, immunostained lesions showed submucosal lobules of capillaries lined by GLUT-1 (glucose transporter isoform 1)-positive endothelium in IHs, whereas VMs consisted of loosely organized venous channels that lacked GLUT-1 staining.
CONCLUSION: Patients with airway IHs and VMs differ in presenting age and signs, sex, airway lesion location, enhancement on computed tomographic angiograms, and histologic appearance.
Nooshin Parhizkar; Scott C Manning; Andrew F Inglis; Laura S Finn; Eunice Y Chen; Jonathan A Perkins
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-01-17
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  137     ISSN:  1538-361X     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-06-30     Revised Date:  2014-06-01    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  AIM; IM    
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MeSH Terms
Arteriovenous Malformations / pathology*,  radiography,  therapy
Child, Preschool
Diagnosis, Differential
Hemangioma / pathology*,  radiography,  therapy
Respiratory System / blood supply*
Respiratory Tract Neoplasms / pathology*,  radiography,  therapy
Tomography, X-Ray Computed
Grant Support

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