Document Detail

Housing and rank status of male Long-Evans rats modify ethanol's effect on open-field behaviors.
MedLine Citation:
PMID:  16508762     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Psychosocial stress is known to alter behavior of rodents. While psychosocial stress may alter the response to some drugs, the response to ethanol (EtOH) has not been evaluated. OBJECTIVE: To examine open-field behaviors of triad- and singly housed rats treated acutely or voluntarily ingesting EtOH. METHOD: Triad-housed rats were categorized as dominant, subdominant, or subordinate based on assessments of offensive and defensive behaviors. Open-field behaviors were monitored during a 10-min test in rats voluntarily ingesting a 6% solution of EtOH for 2 weeks (1), and after an i.p. injection of saline, 0.5 or 1.0 g kg(-1) of EtOH (2). RESULTS: Daily intake of EtOH was highest in subdominant and lowest in dominant rats. Overall, open-field behaviors did not differ between water- and EtOH-consuming triad- or singly housed rats. The 0.5-g kg(-1) dose of EtOH enhanced locomotor activity only in triad-housed rats, center entries primarily in singly housed rats, and head-poke behavior in dominant and singly housed rats. Rearing behavior was not altered by the 0.5-g kg(-1) dose, but in singly housed rats, rearing behavior was depressed by the 1.0-g kg(-1) dose. This larger dose of EtOH had no effect on the other behaviors. CONCLUSIONS: EtOH's effects on open-field behaviors show behavioral specificity and vary with the subject's housing and/or rank status. EtOH's acute anxiolytic-like effect was primarily evident in singly housed rats.
Larissa A Pohorecky
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-03-01
Journal Detail:
Title:  Psychopharmacology     Volume:  185     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  289-97     Citation Subset:  IM    
Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, NJ 08854-1100, USA.
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MeSH Terms
Adaptation, Psychological
Behavior, Animal
Ethanol / pharmacology*
Rats, Long-Evans
Social Behavior*
Social Dominance
Social Isolation
Stress, Psychological / psychology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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