Document Detail

Household endotoxin levels and the risk of non-Hodgkin lymphoma.
MedLine Citation:
PMID:  23277417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that increased levels of household endotoxin would be associated with an increased NHL risk.
METHODS: We evaluated this association in the National Cancer Institute/Surveillance, Epidemiology and End Results (NCI/SEER) NHL multicenter population-based case-control study. Used vacuum cleaner bags were collected from participants during a home interview. Dust samples from the bags of 594 cases and 442 controls were analyzed for endotoxin [endotoxin unit (EU)/mg of dust] using the kinetic chromogenic Limulus amebocyte lysate assay. Multivariable logistic regression was used to estimate the effect of endotoxin on NHL risk adjusted for age, sex, race, education, study center, and farm exposure.
RESULTS: Endotoxin was not associated with NHL overall [odds ratio (OR) for highest quartile of endotoxin levels = 0.81, 95 % confidence interval (CI) = 0.55, 1.20; p for trend = 0.35] or with diffuse large B-cell lymphoma (OR = 0.63, 95 % CI = 0.34, 1.16; p = 0.31) or follicular lymphoma (OR = 1.07, 95 % CI = 0.61, 1.89; p = 0.73) subtypes. Both working and living on a farm were associated with higher household endotoxin levels compared to never working (p = 0.009) or living (p = 0.01) on a farm. Excluding farmers from the analysis did not change the results.
CONCLUSIONS: We found no evidence of a role for household endotoxin in NHL etiology.
Jun Wang; Wendy Cozen; Peter S Thorne; Kiros Berhane; James R Cerhan; Patricia Hartge; Mary H Ward; Anneclaire J De Roos; Richard K Severson; Lindsay M Morton; Leslie Bernstein; Martha S Linet; Joanne S Colt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-01
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  24     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-10-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Endotoxins / poisoning*
Environmental Exposure / adverse effects*
Family Characteristics
Genetic Predisposition to Disease
Lymphoma, Non-Hodgkin / chemically induced,  epidemiology*,  genetics
Middle Aged
Risk Factors
SEER Program
United States / epidemiology
Grant Support
N01 PC065064/PC/NCI NIH HHS; N01-PC-35139/PC/NCI NIH HHS; N01-PC-67008/PC/NCI NIH HHS; N01-PC-71105/PC/NCI NIH HHS; N01-PC67009/PC/NCI NIH HHS; P01 CA17054/CA/NCI NIH HHS; P30 CA014089/CA/NCI NIH HHS; P30 ES005605/ES/NIEHS NIH HHS; P30 ES005605/ES/NIEHS NIH HHS; P30 ES07048/ES/NIEHS NIH HHS; U55/CCR921930-02//PHS HHS; ZIA CP010125-15/CP/NCI NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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