| Household chemicals, immune function, and allergy: A commentary. | |
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MedLine Citation:
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PMID: 22953700 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this increased susceptibility to allergy and asthma. Certainly, the changes recorded have been too rapid to implicate a change in the gene pool, and for that reason attention has focused on the possible impact of environmental, dietary, and lifestyle factors. Although the hygiene hypothesis proposes that increased susceptibility to allergic sensitization is associated with changes in childhood exposure pathogenic microorganisms, other factors have been considered also. Among these is exposure to chemicals and atmospheric pollutants. There is some evidence that exposure to certain chemicals may elicit or exacerbate respiratory reactions in those who are already sensitized, or who already have existing airway disease. However, a recent article has proposed that exposure to specific household cleaning products may be one factor that is able to affect susceptibility to allergic sensitization. In the light of that article it is timely now to consider again the ability of chemical exposure to influence sensitization to common antigens. |
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Authors:
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Ian Kimber; Raymond Pieters |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-7 |
Journal Detail:
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Title: Journal of immunotoxicology Volume: - ISSN: 1547-6901 ISO Abbreviation: J Immunotoxicol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101201960 Medline TA: J Immunotoxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Life Sciences, University of Manchester , Manchester , UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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