| Household smoking behavior: effects on indoor air quality and health of urban children with asthma. | |
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MedLine Citation:
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PMID: 20401688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of the study was to examine the association between biomarkers and environmental measures of second hand smoke (SHS) with caregiver, i.e. parent or legal guardian, report of household smoking behavior and morbidity measures among children with asthma. Baseline data were drawn from a longitudinal intervention for 126 inner city children with asthma, residing with a smoker. Most children met criteria for moderate to severe persistent asthma (63%) versus mild intermittent (20%) or mild persistent (17%). Household smoking behavior and asthma morbidity were compared with child urine cotinine and indoor measures of air quality including fine particulate matter (PM(2.5)) and air nicotine (AN). Kruskal-Wallis, Wilcoxon rank-sum and Spearman rho correlation tests were used to determine the level of association between biomarkers of SHS exposure and household smoking behavior and asthma morbidity. Most children had uncontrolled asthma (62%). The primary household smoker was the child's caregiver (86/126, 68%) of which 66 (77%) were the child's mother. Significantly higher mean PM(2.5), AN and cotinine concentrations were detected in households where the caregiver was the smoker (caregiver smoker: PM(2.5) μg/m(3): 44.16, AN: 1.79 μg/m(3), cotinine: 27.39 ng/ml; caregiver non-smoker: PM(2.5): 28.88 μg/m(3), AN: 0.71 μg/m(3), cotinine:10.78 ng/ml, all P ≤ 0.01). Urine cotinine concentrations trended higher in children who reported 5 or more symptom days within the past 2 weeks (>5 days/past 2 weeks, cotinine: 28.1 ng/ml vs. <5 days/past 2 weeks, cotinine: 16.2 ng/ml; P = 0.08). However, environmental measures of SHS exposures were not associated with asthma symptoms. Urban children with persistent asthma, residing with a smoker are exposed to high levels of SHS predominantly from their primary caregiver. Because cotinine was more strongly associated with asthma symptoms than environmental measures of SHS exposure and is independent of the site of exposure, it remains the gold standard for SHS exposure assessment in children with asthma. |
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Authors:
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Arlene M Butz; Patrick Breysse; Cynthia Rand; Jean Curtin-Brosnan; Peyton Eggleston; Gregory B Diette; D'Ann Williams; John T Bernert; Elizabeth C Matsui |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Maternal and child health journal Volume: 15 ISSN: 1573-6628 ISO Abbreviation: Matern Child Health J Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: 2011-08-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9715672 Medline TA: Matern Child Health J Country: United States |
Other Details:
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Languages: eng Pagination: 460-8 Citation Subset: IM |
Affiliation:
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Division of General Pediatrics, The Johns Hopkins University School of Medicine, 200 N. Wolfe St, Baltimore, MD 21287, USA. abutz@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollution, Indoor
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analysis* Asthma* Child Cotinine / urine Data Collection Female Housing* Humans Male Smoking* Tobacco Smoke Pollution United States Urban Population* |
| Grant Support | |
ID/Acronym/Agency:
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E09606//PHS HHS; P01 ES009606-09/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tobacco Smoke Pollution; 486-56-6/Cotinine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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