Document Detail

House dust mites and their allergens at selected locations in the homes of house dust mite-allergic patients.
MedLine Citation:
PMID:  12220467     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Knowledge of the occurrence of house dust mites (HDM) and their allergens in domestic locations is important when planning intervention. OBJECTIVE: The aim of this study was to describe the distribution of HDMs and their allergens before intervention in multiple locations in the homes of newly diagnosed HDM-allergic patients with a known high Der 1 concentration in their mattress dust. METHODS: Dust was collected from ten locations in the homes of eight HDM-allergic patients. Dust was analysed for allergen content with ELISAs for Der f 1, Der p 1 and Der m 1; and HDM were counted. Total allergen concentrations ( micro g Der 1/g dust) were expressed as the sum of Der f 1, Der p 1 and Der m 1. RESULTS: On mattresses the median concentration was 86 micro g Der 1/g dust (range 30-288) and 188 mites/g dust (range 12-1910). Der 1 exceeded 10 micro g/g dust in mattresses (8/8), duvets/pillows (3/8), a bedroom carpet (1/1), a living room carpet (1/6), upholstered furniture (2/8) and a curtain (1/5). Uncarpeted floors, upholstered furniture, bookshelves and walls had significantly lower Der 1 concentration than the mattresses. The relative contribution of Der p 1, Der f 1 or Der m 1 to Der 1 was related to homes, rather than to the location. Der m 1 only occurred in minute amounts. CONCLUSION: For HDM intervention, our results indicate that priority should be given to the removal of allergens from mattresses, and in addition from carpets, duvets/pillows and upholstered furniture. Dust from walls, uncarpeted floors, bookshelves and curtains appear to contribute insignificantly to the domestic HDM allergen load.
K E Sidenius; T E Hallas; T Brygge; L K Poulsen; H Mosbech
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  32     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1299-304     Citation Subset:  IM    
Allergy Unit, National University Hospital, Copenhagen, Denmark.
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MeSH Terms
Antigens, Dermatophagoides / analysis*,  immunology
Bedding and Linens
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Hypersensitivity, Immediate / immunology*
Interior Design and Furnishings
Statistics, Nonparametric
Reg. No./Substance:
0/Antigens, Dermatophagoides; EC 3.4.22.-/Dermatophagoides farinae antigen f 1; EC 3.4.22.-/Dermatophagoides pteronyssinus antigen p 1

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