Document Detail

House dust induces IL-6 and IL-8 response in A549 epithelial cells.
MedLine Citation:
PMID:  10649856     Owner:  NLM     Status:  MEDLINE    
The in vitro potency of house dust to induce cytokine response in A549 lung epithelial cells was studied. Dusts collected from carpet, bed, shelf and floor of a villa and an apartment by vacuuming were found to trigger the production of interleukin-8 (IL-8) and interleukin-6 (IL-6) in a dose-dependent manner, and the interleukin production was several-fold higher than of swine dust (used as a positive control). The IL-8 and IL-6 production of pure Escherichia coli lipopolysaccharide was significantly lower than of the dusts and a peptidoglycan-polysaccharide complex did not show any stimulatory effect at all. The lipopolysaccharide and peptidoglycan contents of the samples were determined by gas chromatography-tandem mass spectrometry analysis of, respectively, 3-hydroxy fatty acids and muramic acid; in addition, ergosterol was monitored for fungal biomass. The inflammatory properties of house dust upon inhalation may be reflected in its high potency to induce cytokine response in lung epithelial cells.
A Saraf; L Larsson; B M Larsson; K Larsson; L Palmberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indoor air     Volume:  9     ISSN:  0905-6947     ISO Abbreviation:  Indoor Air     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-09     Completed Date:  2000-02-09     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9423515     Medline TA:  Indoor Air     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Department of Infectious Diseases and Medical Microbiology, University of Lund, Sweden.
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MeSH Terms
Air Pollution, Indoor / adverse effects*
Cell Line
Epithelial Cells / immunology
Inhalation Exposure
Interleukin-6 / biosynthesis*,  immunology
Interleukin-8 / biosynthesis*,  immunology
Lung / drug effects,  immunology*
Reg. No./Substance:
0/Dust; 0/Interleukin-6; 0/Interleukin-8

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