Document Detail


House dust (1-3)-beta-D-glucan and wheezing in infants.
MedLine Citation:
PMID:  17441791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: (1-3)-Beta-D-glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1-3)-beta-D-glucan during infancy. We examined the association between (1-3)-beta-D-glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.
METHODS: (1-3)-Beta-D-glucan and endotoxin exposures were measured in settled dust collected from infants' primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.
RESULTS: Exposure to high (1-3)-beta-D-glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95% CI = 0.16-0.93] and recurrent wheezing combined with allergen sensitization (aOR = 0.13, 95% CI = 0.03-0.61). Similar trends were found between (1-3)-beta-D-glucan concentrations and allergen sensitization (aOR = 0.57, 95% CI = 0.30-1.10). In contrast, recurrent wheezing with or without allergen sensitization was positively associated with low (1-3)-beta-D-glucan exposure within the first quartile (aOR = 3.04, 95% CI = 1.25-7.38; aOR = 4.89, 95% CI = 1.02-23.57). There were no significant associations between endotoxin exposure and the studied health outcomes.
CONCLUSIONS: This is the first study to report that indoor exposure to high levels of (1-3)-beta-D-glucan (concentration >60 microg/g) is associated with decreased risk for recurrent wheezing among infants born to atopic parents. This effect was more pronounced in the subgroup of allergen-sensitized infants.
Authors:
Y Y Iossifova; T Reponen; D I Bernstein; L Levin; H Kalra; P Campo; M Villareal; J Lockey; G K K Hershey; G LeMasters
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Allergy     Volume:  62     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-19     Completed Date:  2007-07-17     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  504-13     Citation Subset:  IM    
Affiliation:
Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects,  immunology
Dust / immunology*
Endotoxins / immunology
Female
Humans
Infant
Male
Respiratory Hypersensitivity / immunology
Respiratory Sounds / etiology,  immunology*
beta-Glucans / immunology*
Grant Support
ID/Acronym/Agency:
ES11170/ES/NIEHS NIH HHS; R01 ES011170-05S1/ES/NIEHS NIH HHS; T42/CCT510420//PHS HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Dust; 0/Endotoxins; 0/beta-1,3-D-glucan; 0/beta-Glucans
Comments/Corrections

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