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Hot water epilepsy clinical profile and treatment-A prospective study.
MedLine Citation:
PMID:  22727658     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: This study characterized the demographic, clinical, EEG and imaging profile, and therapeutic outcome among patients with hot water epilepsy (HWE). Methodology This prospective study included 70 patients with HWE (M:F=55:15; age: 25.3±8.4years). Details of demography, seizure characteristics and outcome, and imaging/EEG observations were recorded. RESULT: There was male dominance. Majority of the patients belonged to Mandya: 30.5%, Ramanagara: 30.0% and Mysore: 15.2% districts of Karnataka, India. Forty-five patients (M:F=37:8; age: 24.6±10.1years) had features of 'HWE alone'. Twenty-five (M:F=18:7; age: 26.7±7.9years) had HWE with spontaneous seizures. The age at onset of seizures was comparable in both the groups - HWE: 18.7±10.2years vs. HWE with spontaneous seizure: 16.8±10.3years (p=0.34). The duration of seizures were more in HWE with spontaneous seizure group: 119.5±66.9months compared to HWE alone: 69.9±13.8months (p=0.028). Inter-ictal EEG (n=70) showed epileptiform activities in 15 patients (21.4%). The therapeutic outcome after 3-8months of follow up were - (a) HWE group: 6 stopped hot water head bath; 39 were on intermittent clobazam therapy - seizure free: 33; and 6 received AEDs; (b) HWE with spontaneous seizure group: all were on AEDs and seizure free. CONCLUSIONS: Three-fourth of patients belonged to 'Mandya-Mysore belt of Karnataka'. There was increased duration of seizures among those with additional spontaneous seizure. About 3/4th subjects with HWE alone were seizure free with intermittent clobazam and remaining patients on AEDs were seizure free, confirming the earlier observations from this center.
Authors:
A Meghana; S Sinha; T N Sathyaprabha; D K Subbakrishna; P Satishchandra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Epilepsy research     Volume:  -     ISSN:  1872-6844     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurophysiology, National Institute of Mental Health and Neuroscience (NIMHANS), Bangalore, India.
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