Document Detail


Hot topics in aging research: protein translation and TOR signaling, 2010.
MedLine Citation:
PMID:  21176090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of other cellular processes, to modulate longevity and healthspan in evolutionarily diverse species. This Hot Topics review will cover important new findings in this area that have occurred over the past year. These include the demonstration that the TOR substrate ribosomal S6 kinase modulates longevity in mammals, the potential for TOR inhibitors as therapeutic treatments for Alzheimer's disease, and further studies emphasizing the importance of differential translation of specific mRNAs for healthy aging and enhanced longevity.
Authors:
Matt Kaeberlein; Brian K Kennedy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-20
Journal Detail:
Title:  Aging cell     Volume:  10     ISSN:  1474-9726     ISO Abbreviation:  Aging Cell     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-07-05     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  101130839     Medline TA:  Aging Cell     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Dietary Supplements
Humans
Immunosuppressive Agents / administration & dosage,  pharmacology
Longevity / drug effects,  genetics
Mice
Protein Biosynthesis*
Research*
Ribosomal Protein S6 Kinases / genetics,  metabolism
Signal Transduction / physiology*
Sirolimus / administration & dosage,  pharmacology
TOR Serine-Threonine Kinases / metabolism*
Grant Support
ID/Acronym/Agency:
R01 AG031108/AG/NIA NIH HHS; R01 AG031108-04/AG/NIA NIH HHS; R01AG025549/AG/NIA NIH HHS; R01AG031108/AG/NIA NIH HHS; R01AG033373/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.11.1/Ribosomal Protein S6 Kinases; W36ZG6FT64/Sirolimus
Comments/Corrections

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