Document Detail


Hot topics in aging research: protein translation, 2009.
MedLine Citation:
PMID:  19747234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the last few years, links between regulation of mRNA translation and aging have been firmly established in invertebrate model organisms. This year, a possible relationship between mRNA translation and aging in mammals has been established with the report that rapamycin increases lifespan in mice. Other significant findings have connected translation control with other known longevity pathways and provided fodder for mechanistic hypotheses. Here, we summarize advances in this emerging field and raise questions for future studies.
Authors:
Brian K Kennedy; Matt Kaeberlein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-11
Journal Detail:
Title:  Aging cell     Volume:  8     ISSN:  1474-9726     ISO Abbreviation:  Aging Cell     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-14     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  101130839     Medline TA:  Aging Cell     Country:  England    
Other Details:
Languages:  eng     Pagination:  617-23     Citation Subset:  IM    
Affiliation:
Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA. bkenn@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Humans
Protein Biosynthesis*
Protein Kinases / genetics,  metabolism
RNA, Messenger / genetics*
TOR Serine-Threonine Kinases
Grant Support
ID/Acronym/Agency:
R01 AG 025549/AG/NIA NIH HHS; R01 AG 031108/AG/NIA NIH HHS; R01 AG 033373/AG/NIA NIH HHS; R01 AG025549/AG/NIA NIH HHS; R01 AG031108/AG/NIA NIH HHS; R01 AG033373/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; EC 2.7.-/Protein Kinases; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.1.1/mTOR protein, mouse
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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