Document Detail

Hot occupation and nephrolithiasis.
MedLine Citation:
PMID:  8230496     Owner:  NLM     Status:  MEDLINE    
We investigated the prevalence of stone disease and urinary stone risk factors in machinists chronically exposed to a hot environment and massive sweating, without interference of nephrotoxic metals or other lithogenic compounds. The study was performed at a glass plant and exposure to heat stress was estimated by the Wet Bulb Globe Temperature climatic index. The prevalence of nephrolithiasis on the entire population of the machinists was 8.5% (20 of 236), while the prevalence on the controls working in normal temperature was 2.4% (4 of 165) (p = 0.03). A high incidence (38.8%) of uric acid stones was present in the workers exposed to heat stress. Among the urinary stone risk indexes determined for 3 days during the 8-hour work shift on a randomly selected sample of 21 workers exposed and 21 workers not exposed to heat stress without any evidence of stone disease significant differences were found in uric acid concentration (722 +/- 195 versus 482 +/- 184 mg./l., p < 0.001), specific gravity (1,026 +/- 4 versus 1,021 +/- 6, p < 0.005) and pH (5.31 +/- 0.28 versus 5.64 +/- 0.54, p < 0.02), respectively. Thus, high uric acid relative supersaturation was present during occupation in hot temperatures (8.67 +/- 3.49) compared to occupation in normal temperatures (4.15 +/- 2.7) (p < 0.001). This study confirms that chronic dehydration represents a real lithogenic risk factor, mainly for uric acid stones, and adequate fluid intake is recommended during hot occupations.
L Borghi; T Meschi; F Amato; A Novarini; A Romanelli; F Cigala
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  150     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1993-12-10     Completed Date:  1993-12-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1757-60     Citation Subset:  AIM; IM    
Institute of Semeiotica Medica, University of Parma and Medicina Preventiva e Igiene del Lavoro, Parma, Italy.
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MeSH Terms
Dehydration / etiology*
Hot Temperature / adverse effects*
Italy / epidemiology
Kidney Calculi / chemistry,  epidemiology*,  etiology
Occupational Diseases / epidemiology*,  etiology
Occupational Exposure*
Risk Factors
Stress, Physiological / etiology
Uric Acid / analysis
Reg. No./Substance:
69-93-2/Uric Acid

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