| Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapy. | |
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MedLine Citation:
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PMID: 20443719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Menopausal hot flushes may affect the responses of various vascular risk factors to hormone therapy (HT). We compared the responses of biochemical markers for cardiovascular diseases to HT in recently postmenopausal women with tolerable or intolerable hot flushes. METHODS: Healthy, non-smoking freshly postmenopausal women (n = 150) with no previous HT use were studied. Seventy-two women reported intolerable hot flushes (> or =7 moderate/severe episodes/day) and 78 women tolerable hot flushes (< or =3 mild episodes/day). The participants were treated in randomized order with either transdermal estradiol gel (1 mg), oral estradiol valerate (2 mg) with or without medroxyprogesterone acetate (5 mg), or placebo for 6 months. Treatment-induced changes in lipids, lipoproteins, apolipoproteins, sex hormone binding globulin (SHBG) and high-sensitivity C-reactive protein were compared. The trial is registered in the US National Institutes of Health Clinical Research Registry (no. NCT00668603). RESULTS: Pretreatment hot flush status was not related to the responses of these markers to different forms of HT. However, when all active regimens were evaluated together as a post-hoc analysis, 7/10 markers showed a tendency toward greater beneficial changes in women with intolerable hot flushes. Furthermore, in women with intolerable hot flushes and with HT use, the increases in SHBG (Spearman's rho = - 0.570, p < 0.001) were related to the reductions in hot flushes during the use of HT. CONCLUSIONS: Hot flushes appear to be no significant determinant for the responses of vascular markers to HT use. |
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Authors:
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P Tuomikoski; T S Mikkola; M J Tikkanen; O Ylikorkala |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Climacteric : the journal of the International Menopause Society Volume: 13 ISSN: 1473-0804 ISO Abbreviation: Climacteric Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-26 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810959 Medline TA: Climacteric Country: England |
Other Details:
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Languages: eng Pagination: 457-66 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00668603 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Oral Apolipoprotein A-I / blood Apolipoproteins B / blood Biological Markers / blood C-Reactive Protein / analysis Cardiovascular Diseases / blood*, diagnosis Estradiol / administration & dosage Estrogen Replacement Therapy / methods* Estrogens / administration & dosage Female Hot Flashes / blood, drug therapy* Humans Medroxyprogesterone Acetate / administration & dosage Middle Aged Postmenopause / blood*, drug effects Sex Hormone-Binding Globulin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Biological Markers; 0/Estrogens; 0/Sex Hormone-Binding Globulin; 50-28-2/Estradiol; 71-58-9/Medroxyprogesterone Acetate; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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