| Hostility and adiposity mediate disparities in insulin resistance among adolescents and young adults. | |
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MedLine Citation:
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PMID: 20542297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study explores whether the relationship between lower socioeconomic status and insulin resistance in adolescents is mediated by both physiological and psychological factors associated with increased cardiometabolic risk. STUDY DESIGN: School-based longitudinal cohort study of 1222 healthy, non-Hispanic black and white teens. Parent education (PE), youth-specific Cook-Medley hostility scale, waist circumference, height, weight, pubertal status, and fasting plasma insulin (FPI) were measured and FPI reassessed 1 year later. Regression analyses utilizing bootstrapping (n=2000) were used to estimate the direct and indirect effects of PE on FPI and assess the role of hostility and adiposity while adjusting for covariates. RESULTS: Lower PE predicted higher FPI (B=-1.52, P=.003), as did hostility (B=.19, P=.002) and adiposity (waist circumference B=.44, P<.001, BMI B=.98, P<.001). The effect of PE on FPI was mediated by both hostility and adiposity. When adiposity and hostility were accounted for, the effect of PE on FPI decreased by 32% (B=-1.04, P=.04); the total indirect estimate was -.485 (95% CI, -.652, -.041). Hostility accounted for 36% of the meditational effect. CONCLUSIONS: Lower PE influences insulin resistance through adiposity and hostility. Thus, interventions to reduce health disparities associated with insulin resistance should consider both physiological and psychological approaches. |
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Authors:
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Elizabeth Goodman; Aviva Must; Stephen R Daniels; Lawrence M Dolan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-14 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 157 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-10-08 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 572-7, 577.e1 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Floating Hospital for Children at Tufts Medical Center, Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02114, USA. egoodman3@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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ethnology Adolescent African Continental Ancestry Group / statistics & numerical data* Body Mass Index Cardiovascular Diseases / ethnology* Cohort Studies European Continental Ancestry Group / statistics & numerical data* Female Hostility* Humans Insulin Resistance / ethnology* Male Obesity / ethnology* Prospective Studies School Health Services Socioeconomic Factors Waist Circumference Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DK59183/DK/NIDDK NIH HHS; HD41527/HD/NICHD NIH HHS; M01RR 08084/RR/NCRR NIH HHS; R01 HD041527-01/HD/NICHD NIH HHS; R01 HD041527-03/HD/NICHD NIH HHS; R01 HD041527-08A2/HD/NICHD NIH HHS; R01 HD041527-09/HD/NICHD NIH HHS; R01 HD041527-10/HD/NICHD NIH HHS; R01 HD041527-11/HD/NICHD NIH HHS; R01 HD041527-12/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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