| Host signal transduction and endocytosis of Campylobacter jejuni. | |
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MedLine Citation:
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PMID: 8905618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caveolae are plasma membrane invaginations found in a variety of mammalian cells and are implicated in clathrin-independent endocytosis and signal transduction. Here we show that pretreatment of Caco-2 cell monolayers with filipin III, which disrupts caveolae by chelating cholesterol, significantly reduces the ability of Campylobacter jejuni to enter these cells. Furthermore inhibitors of host protein tyrosine phosphorylation, the phosphatidylinositol-3 kinase (Pl 3-kinase) inhibitor wortmannin, and cholera toxin, all significantly reduced invasion of Caco-2 cells by C. jejuni. |
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Authors:
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K G Wooldridge; P H Williams; J M Ketley |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microbial pathogenesis Volume: 21 ISSN: 0882-4010 ISO Abbreviation: Microb. Pathog. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-03-05 Completed Date: 1997-03-05 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 8606191 Medline TA: Microb Pathog Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 299-305 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of Leicester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstadienes
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pharmacology Caco-2 Cells Campylobacter jejuni / pathogenicity* Cell Membrane Chelating Agents / pharmacology Cholera Toxin / pharmacology Dose-Response Relationship, Drug Endocytosis / drug effects* Enzyme Inhibitors / pharmacology Filipin / pharmacology Humans Intestines / cytology, microbiology* Signal Transduction Staurosporine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Chelating Agents; 0/Enzyme Inhibitors; 19545-26-7/wortmannin; 480-49-9/Filipin; 62996-74-1/Staurosporine; 9012-63-9/Cholera Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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