Document Detail

Host signal transduction and endocytosis of Campylobacter jejuni.
MedLine Citation:
PMID:  8905618     Owner:  NLM     Status:  MEDLINE    
Caveolae are plasma membrane invaginations found in a variety of mammalian cells and are implicated in clathrin-independent endocytosis and signal transduction. Here we show that pretreatment of Caco-2 cell monolayers with filipin III, which disrupts caveolae by chelating cholesterol, significantly reduces the ability of Campylobacter jejuni to enter these cells. Furthermore inhibitors of host protein tyrosine phosphorylation, the phosphatidylinositol-3 kinase (Pl 3-kinase) inhibitor wortmannin, and cholera toxin, all significantly reduced invasion of Caco-2 cells by C. jejuni.
K G Wooldridge; P H Williams; J M Ketley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbial pathogenesis     Volume:  21     ISSN:  0882-4010     ISO Abbreviation:  Microb. Pathog.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8606191     Medline TA:  Microb Pathog     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Department of Genetics, University of Leicester, UK.
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MeSH Terms
Androstadienes / pharmacology
Caco-2 Cells
Campylobacter jejuni / pathogenicity*
Cell Membrane
Chelating Agents / pharmacology
Cholera Toxin / pharmacology
Dose-Response Relationship, Drug
Endocytosis / drug effects*
Enzyme Inhibitors / pharmacology
Filipin / pharmacology
Intestines / cytology,  microbiology*
Signal Transduction
Staurosporine / pharmacology
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Androstadienes; 0/Chelating Agents; 0/Enzyme Inhibitors; 19545-26-7/wortmannin; 480-49-9/Filipin; 62996-74-1/Staurosporine; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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