| Host-pathogen interplay and the evolution of bacterial effectors. | |
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MedLine Citation:
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PMID: 18034865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many bacterial pathogens require a type III secretion system (T3SS) and suite of type III secreted effectors (T3SEs) to successfully colonize their hosts, extract nutrients and consequently cause disease. T3SEs, in particular, are key components of the bacterial arsenal, as they function directly inside the host to disrupt or suppress critical components of the defence network. The development of host defence and surveillance systems imposes intense selective pressures on these bacterial virulence factors, resulting in a host-pathogen co-evolutionary arms race. This arms race leaves its genetic signature in the pattern and structure of natural genetic variation found in T3SEs, thereby permitting us to infer the specific evolutionary processes and pressures driving these interactions. In this review, we summarize our current knowledge of T3SS-mediated host-pathogen co-evolution. We examine the evolution of the T3SS and the T3SEs that traverse it, in both plant and animal pathosystems, and discuss the processes that maintain these important pathogenicity determinants within pathogen populations. We go on to examine the possible origins of T3SEs, the mechanisms that give rise to new T3SEs and the processes that underlie their evolution. |
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Authors:
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John Stavrinides; Honour C McCann; David S Guttman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-11-21 |
Journal Detail:
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Title: Cellular microbiology Volume: 10 ISSN: 1462-5822 ISO Abbreviation: Cell. Microbiol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 285-92 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolution, University of Arizona, 1007 E Lowell Street, Tucson, AZ 85721, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Biological Animals Bacterial Proteins / genetics*, metabolism, physiology Bacteriophages / genetics Evolution, Molecular* Plants / microbiology Recombination, Genetic Virulence Factors / genetics*, metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Virulence Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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