| Host-pathogen interactions: Cell death and infection: A double-edged sword for host and pathogen survival. | |
| | |
MedLine Citation:
|
PMID: 22123830 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often suppressing cell death to allow replication and then promoting it for dissemination. Frequently, these effects are exerted through modulation of the mitochondrial pro-death, NF-κB-dependent pro-survival, and inflammasome-dependent host cell death pathways during infection. Understanding the molecular details by which bacterial pathogens manipulate cell death pathways will provide insight into new therapeutic approaches to control infection. |
| | |
Authors:
|
Hiroshi Ashida; Hitomi Mimuro; Michinaga Ogawa; Taira Kobayashi; Takahito Sanada; Minsoo Kim; Chihiro Sasakawa |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
|
Title: The Journal of cell biology Volume: - ISSN: 1540-8140 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Microbiology and Immunology, and 2 Department of Infectious Disease Control, International Research Center for Infectious Disease, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PathVar: analysis of gene and protein expression variance in cellular pathways using microarray data...
Next Document: Host-pathogen interactions: Subversion of membrane transport pathways by vacuolar pathogens.