Document Detail


Host lifestyle affects human microbiota on daily timescales.
MedLine Citation:
PMID:  25146375     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Disturbance to human microbiota may underlie several pathologies. Yet, we lack a comprehensive understanding of how lifestyle affects the dynamics of human-associated microbial communities.
RESULTS: Here, we link over 10,000 longitudinal measurements of human wellness and action to the daily gut and salivary microbiota dynamics of two individuals over the course of one year. These time series show overall microbial communities to be stable for months. However, rare events in each subjects' life rapidly and broadly impacted microbiota dynamics. Travel from the developed to the developing world in one subject led to a nearly two-fold increase in the Bacteroidetes to Firmicutes ratio, which reversed upon return. Enteric infection in the other subject resulted in the permanent decline of most gut bacterial taxa, which were replaced by genetically similar species. Still, even during periods of overall community stability, the dynamics of select microbial taxa could be associated with specific host behaviors. Most prominently, changes in host fiber intake positively correlated with next-day abundance changes among 15% of gut microbiota members.
CONCLUSIONS: Our findings suggest that although human-associated microbial communities are generally stable, they can be quickly and profoundly altered by common human actions and experiences.
Authors:
Lawrence A David; Arne C Materna; Jonathan Friedman; Maria I Campos-Baptista; Matthew C Blackburn; Allison Perrotta; Susan E Erdman; Eric J Alm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-25
Journal Detail:
Title:  Genome biology     Volume:  15     ISSN:  1465-6914     ISO Abbreviation:  Genome Biol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960660     Medline TA:  Genome Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  R89     Citation Subset:  -    
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