| Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy. | |
| | |
MedLine Citation:
|
PMID: 17240235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to define the impact of asymptomatic trichomoniasis on lower genital tract neutrophil activation in pregnancy. STUDY DESIGN: In this nested cohort study, pelvic examination was performed on 65 asymptomatic pregnant women between 7 and 22 weeks' with vaginal pH > 4.4. Concentrations of cervical interleukin-8 and alpha-defensin were determined using enzyme-linked immunosorbent assay (ELISA). Trichomonas vaginalis was detected by culture. RESULTS: Median concentrations of vaginal fluid neutrophil defensins and cervical interleukin-8 were significantly greater among women with asymptomatic trichomoniasis (median defensins 18,622 ng/mL, median IL-8 9244 pg/mL) than their uninfected counterparts (median defensins 5144 ng/mL, median IL-8 2044 pg/mL) (P < .001). All women with asymptomatic trichomoniasis had detectable defensin and interleukin-8 concentrations. CONCLUSION: Asymptomatic trichomoniasis in pregnancy is accompanied by a state of neutrophil activation. |
| | |
Authors:
|
Hyagriv N Simhan; Brenna L Anderson; Marijane A Krohn; R Phillips Heine; Begoña Martinez de Tejada; Daniel V Landers; Sharon L Hillier |
Related Documents
:
|
12913335 - Non-viable cervico-isthmic pregnancy: the importance of an accurate sonographic diagnos... 3522005 - Operations for cervical incompetence. 16443225 - Cervical gland area as an ultrasonographic marker for preterm delivery. 16181705 - Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lum... 19050325 - Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during ges... 2268565 - Ultrasound femur length as a means of assessing gestational age amongst nigerians. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 196 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2007 Jan |
Date Detail:
|
Created Date: 2007-01-22 Completed Date: 2007-03-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 59.e1-5 Citation Subset: AIM; IM |
Affiliation:
|
Division of Maternal-Fetal Medicine, Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Cohort Studies Female Humans Interleukin-8 / biosynthesis Neutrophil Activation* Pregnancy Pregnancy Complications, Parasitic / immunology* Trichomonas Vaginitis / immunology* alpha-Defensins / biosynthesis |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-8; 0/alpha-Defensins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reliability of a preventability model in maternal death and morbidity.
Next Document: Fetal thrombocytopenia secondary to parvovirus infection.