| Host genetic polymorphisms associated with innate immune factors and HIV-1. | |
| | |
MedLine Citation:
|
PMID: 21734565 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Our understanding of the early events in HIV-1 infection continues to grow, along with the heightened recognition of the important contribution that innate immunity plays in response to HIV-1. Here, we review the epidemiological and functional studies of genetic polymorphisms associated with innate immune factors that are believed to modulate host responses, focusing specifically on recent findings related to Toll-like receptor, cytokine, host restriction and KIR genes and their activities. RECENT FINDINGS: A growing number of genomic studies have described polymorphisms in innate immune genes that are associated with early postseroconversion events, including TLR4, TLR9, IRF-3, TRIM5α and the ABOBEC3 gene family. Genetic and functional data confirm the importance of KIR-HLA interactions and provide new understanding of the role of innate restriction factors in resistance to HIV-1 and disease progression. SUMMARY: Single-gene, genome-wide association and expression studies have permitted the identification of innate immune genes and their variants that contribute to protection from disease progression. Characterization of the pathogen-innate immune system interactions and discovery of new and rare host genetic variants that account for a portion of the observed variance in the HIV-1 phenotype is critical to gain new insights into promising treatment and prevention strategies. |
| | |
Authors:
|
Magdalena E Sobieszczyk; Jairam R Lingappa; M Juliana McElrath |
Related Documents
:
|
12014425 - The in vitro anti-inflammatory effects of recombinant anti-cd25 immunotoxin on lamina p... 16951375 - Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: cont... 17720145 - The intestinal anti-inflammatory effects of the novel agent ur-1505 in the tnbs model o... 7709695 - From inflammation to lesion. 20701455 - Natural killer cells as indispensable players and therapeutic targets in autoimmunity. 7561075 - Induction of bcl-x by cd40 engagement rescues sig-induced apoptosis in murine b cells. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-2 |
Journal Detail:
|
Title: Current opinion in HIV and AIDS Volume: - ISSN: 1746-6318 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264945 Medline TA: Curr Opin HIV AIDS Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, New York bDepartments of Global Health and Medicine, University of Washington cVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center dDepartment of Pediatrics, University of Washington, Seattle, Washington, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Macrophages and HIV-1.
Next Document: Targeting HIV-1 innate immune responses therapeutically.