| Host defenses against respiratory tract infection: implications for anti-inflammatory drug development and treatment. | |
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MedLine Citation:
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PMID: 18075827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human respiratory tract is exposed to a constantly changing environment which may bring it into contact with a variety of pathogenic organisms. A range of innate and acquired defence mechanisms have evolved to counter these threats. Several new classes of therapeutic agent which may interfere with these defence mechanisms have recently been marketed or are under clinical development; this paper reviews some key examples, with the potential implications for disease management. |
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Authors:
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N J C Snell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experimental lung research Volume: 33 ISSN: 0190-2148 ISO Abbreviation: Exp. Lung Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-02-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: United States |
Other Details:
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Languages: eng Pagination: 529-36 Citation Subset: IM |
Affiliation:
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AstraZeneca R&D, Loughborough, UK. noel.snell@astrazeneca.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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immunology,
therapeutic use* Humans Immunity, Innate / immunology* Interleukin-1 / physiology Respiratory Tract Infections / drug therapy*, immunology, physiopathology Toll-Like Receptors / physiology Tumor Necrosis Factor-alpha / physiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Interleukin-1; 0/Toll-Like Receptors; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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