Document Detail


Host defenses against bacterial lower respiratory tract infection.
MedLine Citation:
PMID:  22841348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial pneumonia continues to be a significant cause of morbidity and mortality worldwide. Recent studies have shown that lung epithelia signal through pattern recognition receptors to initiate the innate immune response. Other mediators of innate immunity against bacterial pneumonia include transepithelial dendritic cells, alveolar macrophages, and innate produces of IL-17. CD4+ T cells and B cells play a key role in eliminating and preventing the development of bacterial pneumonias. B cell development and maturation can be modulated by the lung epithelia through BAFF and APRIL, furthering our current understanding of the role of epithelial cells in the immune response.
Authors:
Taylor Eddens; Jay K Kolls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-25
Journal Detail:
Title:  Current opinion in immunology     Volume:  24     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2012-12-07     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  424-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / immunology
Cytokines / metabolism
Humans
Immunity, Innate / physiology*
Immunity, Mucosal / physiology*
Pneumonia, Bacterial / immunology*
Respiratory System / microbiology
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
P50HL084932/HL/NHLBI NIH HHS; R01 HL061271/HL/NHLBI NIH HHS; R01 HL062052/HL/NHLBI NIH HHS; R37 HL079142/HL/NHLBI NIH HHS; R37HL079142/HL/NHLBI NIH HHS; T32 GM008208/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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