| Host-cell factors involved in papillomavirus entry. | |
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MedLine Citation:
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PMID: 22972234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Papillomaviruses infect skin and mucosa where they induce warts and cancers. For entry to occur, they sequentially engage numerous host proteins, allowing them to deliver their genetic information into target cells. This multistep process starts with initial binding via its L1 major capsid protein, followed by structural changes of the capsid on the cell surface, engagement of different receptors, and endocytosis. The post-entry phase includes capsid disassembly, endosomal escape of a complex of the minor capsid protein L2 and the viral genome, its transport into the nucleus, and accumulation at nuclear substructures. This review summarizes the current knowledge of the papillomavirus entry pathway and the role of cellular proteins involved in this course of events. |
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Authors:
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Luise Florin; Martin Sapp; Gilles A Spoden |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-09-13 |
Journal Detail:
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Title: Medical microbiology and immunology Volume: 201 ISSN: 1432-1831 ISO Abbreviation: Med. Microbiol. Immunol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-15 Completed Date: 2013-03-01 Revised Date: 2013-04-25 |
Medline Journal Info:
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Nlm Unique ID: 0314524 Medline TA: Med Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 437-48 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany. lflorin@uni-mainz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Epithelial Cells
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virology Host-Pathogen Interactions* Humans Papillomaviridae / physiology* Virus Internalization* |
| Grant Support | |
ID/Acronym/Agency:
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8 P20 GM103433-10/GM/NIGMS NIH HHS; R01 AI081809/AI/NIAID NIH HHS; R01AI081809/AI/NIAID NIH HHS |
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