Document Detail

Host-cell factors involved in papillomavirus entry.
MedLine Citation:
PMID:  22972234     Owner:  NLM     Status:  MEDLINE    
Papillomaviruses infect skin and mucosa where they induce warts and cancers. For entry to occur, they sequentially engage numerous host proteins, allowing them to deliver their genetic information into target cells. This multistep process starts with initial binding via its L1 major capsid protein, followed by structural changes of the capsid on the cell surface, engagement of different receptors, and endocytosis. The post-entry phase includes capsid disassembly, endosomal escape of a complex of the minor capsid protein L2 and the viral genome, its transport into the nucleus, and accumulation at nuclear substructures. This review summarizes the current knowledge of the papillomavirus entry pathway and the role of cellular proteins involved in this course of events.
Luise Florin; Martin Sapp; Gilles A Spoden
Related Documents :
12223464 - The ins and outs of apc and beta-catenin nuclear transport.
24473594 - Research highlights: microfluidics meets big data.
24865524 - Alteration of mirna activity via context-specific modifications of argonaute proteins.
23086474 - Not all protein-mediated single-wall carbon nanotube dispersions are equally bioactive.
21800424 - Evaluation of protein expression in bovine bronchoalveolar fluid following challenge wi...
10645274 - The mdc family of proteins and their processing during epididymal transit.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-13
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  201     ISSN:  1432-1831     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-01     Revised Date:  2013-04-25    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  437-48     Citation Subset:  IM    
Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Epithelial Cells / virology
Host-Pathogen Interactions*
Papillomaviridae / physiology*
Virus Internalization*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pore-forming bacterial toxins and antimicrobial peptides as modulators of ADAM function.
Next Document:  Long-lived platinum(ii) diimine complexes with broadband excited-state absorption: efficient nonline...