Document Detail


Host-cell factors involved in papillomavirus entry.
MedLine Citation:
PMID:  22972234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Papillomaviruses infect skin and mucosa where they induce warts and cancers. For entry to occur, they sequentially engage numerous host proteins, allowing them to deliver their genetic information into target cells. This multistep process starts with initial binding via its L1 major capsid protein, followed by structural changes of the capsid on the cell surface, engagement of different receptors, and endocytosis. The post-entry phase includes capsid disassembly, endosomal escape of a complex of the minor capsid protein L2 and the viral genome, its transport into the nucleus, and accumulation at nuclear substructures. This review summarizes the current knowledge of the papillomavirus entry pathway and the role of cellular proteins involved in this course of events.
Authors:
Luise Florin; Martin Sapp; Gilles A Spoden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-13
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  201     ISSN:  1432-1831     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-01     Revised Date:  2013-04-25    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  437-48     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany. lflorin@uni-mainz.de
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MeSH Terms
Descriptor/Qualifier:
Epithelial Cells / virology
Host-Pathogen Interactions*
Humans
Papillomaviridae / physiology*
Virus Internalization*
Grant Support
ID/Acronym/Agency:
8 P20 GM103433-10/GM/NIGMS NIH HHS; R01 AI081809/AI/NIAID NIH HHS; R01AI081809/AI/NIAID NIH HHS

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