Document Detail


Host remodeling of the gut microbiome and metabolic changes during pregnancy.
MedLine Citation:
PMID:  22863002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in nonpregnant hosts. Here, to explore their role in pregnancy, we characterized fecal bacteria of 91 pregnant women of varying prepregnancy BMIs and gestational diabetes status and their infants. Similarities between infant-mother microbiotas increased with children's age, and the infant microbiota was unaffected by mother's health status. Gut microbiota changed dramatically from first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness. T3 stool showed strongest signs of inflammation and energy loss; however, microbiome gene repertoires were constant between trimesters. When transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1. Our findings indicate that host-microbial interactions that impact host metabolism can occur and may be beneficial in pregnancy.
Authors:
Omry Koren; Julia K Goodrich; Tyler C Cullender; Aymé Spor; Kirsi Laitinen; Helene Kling Bäckhed; Antonio Gonzalez; Jeffrey J Werner; Largus T Angenent; Rob Knight; Fredrik Bäckhed; Erika Isolauri; Seppo Salminen; Ruth E Ley
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  150     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2012-10-19     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Descriptor/Qualifier:
Actinobacteria / isolation & purification
Animals
Feces / microbiology*
Female
Gastrointestinal Tract / microbiology*
Germ-Free Life
Humans
Infant
Metabolic Syndrome X / microbiology
Metagenome*
Mice
Pregnancy*
Proteobacteria / isolation & purification
Grant Support
ID/Acronym/Agency:
DP2 OD007444/OD/NIH HHS; R01 DK093595/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):560   [PMID:  22907163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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