Document Detail

A Host-Guest Supramolecular Complex with Photoregulated Delivery of Nitric Oxide and Fluorescence Imaging Capacity in Cancer Cells.
MedLine Citation:
PMID:  23015376     Owner:  NLM     Status:  Publisher    
Herein we report the design, preparation, and properties of a supramolecular system based on a tailored nitric oxide (NO) photodonor and a rhodamine-labeled β-cyclodextrin conjugate. The combination of spectroscopic and photochemical experiments shows the absence of significant interchromophoric interactions between the host and the guest in the excited states. As a result, the complex is able to release NO under the exclusive control of visible light, as unambiguously demonstrated by direct detection of this transient species through an amperometric technique, and exhibits the typical red fluorescence of the rhodamine appendage. The supramolecular complex effectively internalizes in HeLa cancer cells as proven by fluorescence microscopy, shows a satisfactory biocompatibility in the dark, and induces about 50 % of cell mortality upon irradiation with visible light. The convergence of all these properties in one single complex makes the present host-guest ensemble an appealing candidate for further delevopment of photoactivatable nanoscaled systems addressed to photostimulated NO-based therapy.
Noufal Kandoth; Milo Malanga; Aurore Fraix; László Jicsinszky; Eva Fenyvesi; Tiziana Parisi; Ivana Colao; Maria Teresa Sciortino; Salvatore Sortino
Related Documents :
10359696 - Wound-induced assembly and closure of an actomyosin purse string in xenopus oocytes.
23831726 - Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical...
23184746 - Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous...
23192966 - Secreted factor r-spondin 2 is involved in refinement of patterning of the mammalian co...
18797916 - Rapid differentiation of superficial urothelial cells after chitosan-induced desquamation.
19521056 - Synchrony between flower opening and petal-color change from red to blue in morning glo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Chemistry, an Asian journal     Volume:  -     ISSN:  1861-471X     ISO Abbreviation:  Chem Asian J     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101294643     Medline TA:  Chem Asian J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, Viale Andrea Doria 6, I-95125 Catania (Italy), Fax: (+39) 095-580138.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  We still have a long way to go to effectively deliver genes!
Next Document:  Overcoming autopsy barriers in pediatric cancer research.