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Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy.
MedLine Citation:
PMID:  22282649     Owner:  NLM     Status:  Publisher    
OBJECTIVE:To study hospitalization for psychiatric disorders before and after onset of unprovoked epileptic seizures/epilepsy. METHOD:In this population-based case-control study, the cases were 1,885 persons from Stockholm with new onset of unprovoked seizures from September 1, 2000, through August 31, 2008, identified in the Stockholm Epilepsy Register. Controls, in total 15,080, were randomly selected from the register of the Stockholm County population. Odds ratios (ORs) were calculated to assess the risk of developing unprovoked epileptic seizures before and after hospitalization for a psychiatric diagnosis defined as a psychiatric hospital discharge diagnosis using International Classification of Disease codes from the Swedish Hospital Discharge Registry. RESULTS:The age-adjusted OR (95% confidence interval) for unprovoked seizures was 2.5 (1.7-3.7) after a hospital discharge diagnosis for depression, 2.7 (1.4-5.3) for bipolar disorder, 2.3 (1.5-3.5) for psychosis, 2.7 (1.6-4.8) for anxiety disorders, and 2.6 (1.7-4.1) for suicide attempts. The risk of developing unprovoked epileptic seizures was highest less than 2 years before and up to 2 years after a first psychiatric diagnosis. CONCLUSION:The increased rate of psychiatric comorbidity predating and succeeding seizure onset indicates a bidirectional relationship and common underlying mechanisms for psychiatric disorders and epilepsy.
Cecilia Adelöw; Tomas Andersson; Anders Ahlbom; Torbjörn Tomson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Clinical Neurosciences (C.A., T.T.) and Institute of Environmental Medicine (T.A., A.A.), Karolinska Institutet, Stockholm, Sweden.
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