Document Detail

Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensure.
MedLine Citation:
PMID:  21793185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7).
PROCEDURE: We performed a retrospective trend analysis of the 1994-2007 Nationwide Inpatient Sample databases. Hospitalizations involving children with SCD and IPD were identified by ICD-9CM code. The primary outcomes, the annual hospitalization rate for IPD in children with SCD and the proportion of hospitalizations for IPD per 100 total SCD hospitalizations, were analyzed using multivariable linear regression and contingency analysis, respectively.
RESULTS: A total of 1,242 hospitalizations for IPD in SCD patients were identified from 1994-2007, with a mortality rate of 2.4%. The national mean annual rate of IPD hospitalization decreased by 65%, from 131.8  cases/year from 1994 to 2000 to 45.5  cases/year from 2001 to 2007 (P = 0.001). The national proportion of hospitalizations for IPD per 100 total SCD hospitalizations decreased from 0.4 to 0.15 (P < 0.0001) over the same interval. Following PCV7 licensure, the mean annual cumulative hospital days and cumulative hospital charges decreased nationally by 53% and 36%, respectively.
CONCLUSION: In a national sample, PCV7 licensure is temporally associated with a nearly threefold reduction in IPD hospitalizations in children with SCD.
Timothy L McCavit; Lei Xuan; Song Zhang; Glenn Flores; Charles T Quinn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-25
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  58     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-03-20     Completed Date:  2012-05-16     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  945-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Anemia, Sickle Cell / complications*,  microbiology
Child, Preschool
Hospitalization / statistics & numerical data*
Pneumococcal Infections / complications*,  epidemiology*,  prevention & control
Pneumococcal Vaccines*
Retrospective Studies
United States
Vaccines, Conjugate
Grant Support
T32 CA009640/CA/NCI NIH HHS; U54 HL0705088-06/HL/NHLBI NIH HHS; UL1 RR024982-03/RR/NCRR NIH HHS
Reg. No./Substance:
0/Pneumococcal Vaccines; 0/Vaccines, Conjugate

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