Document Detail

Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs.
MedLine Citation:
PMID:  8657028     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the incidence of hospital admissions for adverse events related to drug therapy, and to assess whether these drug-related admissions (DRAs) could have been reasonably prevented.
SETTING: A tertiary teaching hospital.
DESIGN AND PATIENTS: Prospective assessment of all admissions through the emergency department and resulting in a stay of more than 24 hours during 30 consecutive days in November and December 1994 to determine if the admission was related to drug therapy. Cases of intentional overdose were excluded.
MAIN OUTCOME MEASURES: The number, type, causality and avoidability of drug-related admissions.
RESULTS: Of 965 admissions, 55 (5.7%) were assessed as being drug-related. Drug-related admissions (DRAs) were designated possibly (38%), probably (46%) or definitely (16%) drug-related; caused by prescribing factors (26%), patient noncompliance (27%) and adverse drug reactions (47%); and classified as definitely (5.5%), possibly (60.0%) and not (34.5%) avoidable. The estimated annual cost to the hospital for all DRAs was $3,496,956 and for unavoidable DRAs was $1,629,494.
CONCLUSION: The DRA rate we found lies around the middle of the range of other published rates. Few DRAs were judged definitely avoidable and over one-third were unavoidable. Nevertheless, the largest proportion were judged possibly avoidable. As the drugs identified in this study are clearly needed in the community, efforts to reduce DRAs must concentrate on education, counselling and monitoring of drug therapy.
J G Dartnell; R P Anderson; V Chohan; K J Galbraith; M E Lyon; P J Nestor; R F Moulds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  164     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-26     Completed Date:  1996-07-26     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  659-62     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Drug Therapy / economics,  statistics & numerical data
Drug-Related Side Effects and Adverse Reactions*
Hospital Costs
Hospitals, Teaching / economics,  utilization
Length of Stay / economics,  statistics & numerical data
Middle Aged
Patient Admission / economics*,  statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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